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Cirrhosis — UKMLA MCQ

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MediumPharmacology & PrescribingCirrhosisUKMLAMRCP Part 1PSA

A 45-year-old man with advanced cirrhosis is prescribed morphine for severe pain. Which adjustment is recommended according to BNF advice in liver disease?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Use reduced doses and titrate carefully

In patients with liver impairment, opioids require lower initial doses and careful titration due to reduced metabolism and increased sensitivity to sedation.

Reference: BNF Opioid Prescribing