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Gastro-oesophageal reflux disease — UKMLA MCQ

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EasyGastroenterologyGastro-oesophageal reflux diseaseUKMLA

A 45-year-old man presents with recurrent episodes of heartburn and acid regurgitation, worsened at night. According to NICE, what is the first-line pharmacological therapy for GORD (gastro-oesophageal reflux disease)?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Proton pump inhibitor (omeprazole)

NICE recommends a full-dose proton pump inhibitor (e.g., omeprazole) for at least 4-8 weeks as the first-line therapy in GORD. H2 receptor antagonists are alternatives. Antacids can provide symptomatic relief but are not definitive first-line. Surgery is for refractory cases.

Reference: NICE GORD Guideline