Uncomplicated UTI — MRCGP AKT MCQ

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EasyRenal medicine & UrologyUncomplicated UTIMRCGP AKT

A 30-year-old woman presents with dysuria and urinary frequency. Urinalysis is positive for nitrites and leukocytes. According to NICE guidance, what is the first-line antibiotic for uncomplicated UTI in a non-pregnant woman?

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Correct answer: C — Nitrofurantoin

Nitrofurantoin (if eGFR adequate) is recommended as first-line for uncomplicated cystitis in non-pregnant women. Trimethoprim can be used if resistance levels are low. Amoxicillin alone is not recommended empirically. The keyed option is the best answer only in the stated clinical context. The alternatives would require different findings, contraindications, thresholds or treatment circumstances that are not present. Apply the recommendation alongside comorbidity, interactions, patient preference and the current local pathway. Review response and safety-net for deterioration, treatment failure or adverse effects; reconsider the diagnosis if the expected response does not occur.

Reference: NICE NG109: https://www.nice.org.uk/guidance/ng109/chapter/recommendations