Depression — PSA MCQ

Instant feedback + full explanation. One question, done properly.

HardPharmacology & PrescribingDepressionPSA

45-year-old with moderate depression not responding to an SSRI for 8 weeks. Which is the next recommended antidepressant option?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Switch to a different SSRI or an SNRI (e.g., venlafaxine)

If a patient fails to respond to an SSRI, guidelines suggest switching to an alternative SSRI or an SNRI such as venlafaxine. Augmentation strategies may be considered if multiple options fail.

Reference: NICE Depression Guideline