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Knowledge Centre / Fever of Unknown Origin (PUO)

Fever of Unknown Origin (PUO)

Investigation of persistent unexplained fever.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)
Last reviewed: 30 August 2025
Infectious DiseasesGeneral PracticeOncology

Clinical Guidelines

UK Standards for Microbiology Investigations - Identification of Pyrexia/Fever of Unknown Origin (PUO, FUO)
National

Recent iatroX Q&As

  • What initial investigations should I consider for a patient presenting with a fever of unknown origin (PUO) lasting more than one week?Updated: 8/22/2025
  • How do I differentiate between infectious and non-infectious causes of PUO in a primary care setting?Updated: 8/22/2025
  • What criteria should I use to decide when to refer a patient with PUO to secondary care for further evaluation?Updated: 8/22/2025
  • Which specific blood tests are most useful in the workup of PUO, and how should I interpret their results?Updated: 8/22/2025
  • What are the recommended management strategies for a patient with PUO who has no clear diagnosis after initial investigations?Updated: 8/22/2025
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