Factor V Leiden

Overview of common inherited thrombophilia.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)

Last reviewed: 21 October 2025

Haematology

Clinical Guidelines

2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism

FSRH Guideline: Combined Hormonal Contraception (October 2023)

NICE guideline [NG158]: Venous thromboembolic diseases: diagnosis, management and thrombophilia testing

Reducing the Risk of Venous Thromboembolism during Pregnancy and the Puerperium (Green-top Guideline No. 37a)

2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack

ACOG Practice Bulletin No. 197: Inherited Thrombophilias in Pregnancy

Addendum: American College of Medical Genetics consensus statement on factor V Leiden mutation testing

American College of Medical Genetics Consensus Statement on Factor V Leiden Mutation Testing

American Society of Hematology 2018 guidelines for management of venous thromboembolism: VTE in the context of pregnancy

American Society of Hematology 2023 guidelines for management of venous thromboembolism: Thrombophilia testing

ASH Clinical Practice Guidelines: Thrombophilia Testing

Guideline: VTE prophylaxis in pregnancy and the puerperium

Practice Bulletin No. 138: Inherited Thrombophilias in Pregnancy

Reducing the Risk of Venous Thromboembolism during Pregnancy and the Puerperium (Green-top Guideline No. 37a)

Technical standards and guidelines: venous thromboembolism (Factor V Leiden and prothrombin G20210A) testing