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Knowledge Centre / Exocrine Pancreatic Insufficiency (EPI)

Exocrine Pancreatic Insufficiency (EPI)

Diagnosis and management of maldigestion due to enzyme deficiency.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)
Last reviewed: 21 October 2025
Gastroenterology

Clinical Guidelines

Consensus for the management of pancreatic exocrine insufficiency: UK practical guidelines
National
NICE guideline [NG104]: Pancreatitis
National
ACG Clinical Guideline: Chronic Pancreatitis
Local
AGA Clinical Practice Update on the Epidemiology, Evaluation, and Management of Exocrine Pancreatic Insufficiency (EPI)
Local

Recent iatroX Q&As

  • What are the key clinical features that suggest a diagnosis of exocrine pancreatic insufficiency in adults?Updated: 8/22/2025
  • Which diagnostic tests are most effective for confirming exocrine pancreatic insufficiency in primary care settings?Updated: 8/22/2025
  • What dietary modifications should I recommend to a patient diagnosed with exocrine pancreatic insufficiency?Updated: 8/22/2025
  • How should I initiate and monitor enzyme replacement therapy in patients with exocrine pancreatic insufficiency?Updated: 8/22/2025
  • When should I consider referring a patient with suspected exocrine pancreatic insufficiency to a specialist?Updated: 8/22/2025
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