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Knowledge Centre / Exocrine Pancreatic Insufficiency (EPI)

Exocrine Pancreatic Insufficiency (EPI)

Diagnosis and management of maldigestion due to enzyme deficiency.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MSt MRCGP (General Practitioner)
Last reviewed: 21 October 2025
Gastroenterology

Clinical Guidelines

Consensus for the management of pancreatic exocrine insufficiency: UK practical guidelines
National
NICE guideline [NG104]: Pancreatitis
National
ACG Clinical Guideline: Chronic Pancreatitis
Local
AGA Clinical Practice Update on the Epidemiology, Evaluation, and Management of Exocrine Pancreatic Insufficiency (EPI)
Local

Recent iatroX Q&As

  • What are the key clinical features that suggest a diagnosis of exocrine pancreatic insufficiency in adults?Updated: 8/22/2025
  • Which diagnostic tests are most effective for confirming exocrine pancreatic insufficiency in primary care settings?Updated: 8/22/2025
  • What dietary modifications should I recommend to a patient diagnosed with exocrine pancreatic insufficiency?Updated: 8/22/2025
  • How should I initiate and monitor enzyme replacement therapy in patients with exocrine pancreatic insufficiency?Updated: 8/22/2025
  • When should I consider referring a patient with suspected exocrine pancreatic insufficiency to a specialist?Updated: 8/22/2025
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