Cancer of Unknown Primary (CUP)

Investigation and management of CUP.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)
Last reviewed: 21 October 2025
Oncology

Clinical Guidelines

ESMO Clinical Practice Guideline: Cancers of Unknown Primary Site
National
ESMO Clinical Practice Guideline: Cancers of Unknown Primary Site
National
NICE Clinical Guidelines, No. 104: Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
National
NICE guideline [CG104]: Metastatic malignant disease of unknown primary origin
National
Cancer of unknown primary: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
Local
Cancer of unknown primary: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
Local
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®): Occult Primary (Cancer of Unknown Primary [CUP])
Local
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®): Occult Primary (Cancer of Unknown Primary [CUP])
Local
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®): Occult Primary (Cancer of Unknown Primary [CUP])
Local