methotrexate sodium · Medicine question

Is methotrexate contraindicated during pregnancy and breastfeeding?

Name: Is methotrexate contraindicated during pregnancy and breastfeeding?
Published: 2026-11-08T14:21:14.143Z

iatroX medicinesPublished 8 November 2026

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Yes, Methotrexate 25 mg/ml Injection, the Hospira UK Ltd product, is contraindicated during pregnancy and breastfeeding, with breastfeeding contraindicated because of potential serious adverse reactions in breastfed infants.

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Methotrexate 25 mg/ml InjectionHospira UK Ltd · emc · SmPC §4.3 Contraindications · Version 28Document updated 7 September 2026

Sources checked 8 November 2026

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