Is it known whether dorzolamide hydrochloride or its metabolites pass into human breast milk?

It is unknown whether dorzolamide hydrochloride (Trusopt) or its metabolites enter human breast milk, although animal data show milk excretion; infant risk cannot be excluded, so breastfeeding or Trusopt therapy must be discontinued or therapy avoided, weighing breastfeeding benefits for the child against treatment benefits for the woman.