Answer
No. Vaginal estriol is local HRT: most of its effect is within vaginal tissues, although some reaches the bloodstream.
Sources for this answer
- NHSNHS · NHS medicine guidance
- Estriol 1mg/g cream — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.