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Medicines burosumabQuestion & answer

burosumab · Medicine question

Is burosumab recommended during pregnancy?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Burosumab is not recommended during pregnancy because human pregnancy data are absent or limited and animal studies have shown reproductive toxicity.

Sources for this answer

Crysvita solution for subcutaneous injectionKyowa Kirin Ltd · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 13Document updated 15 April 2026

Sources checked 8 November 2026

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burosumab

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Is it known whether burosumab passes into human breast milk?How does burosumab affect FGF23 and phosphate reabsorption in the kidneys?How much sorbitol does each vial of Crysvita (burosumab) solution for injection contain?Is burosumab contraindicated in patients with severe renal impairment or end-stage renal disease?What were the most common adverse reactions to burosumab in adults with X-linked hypophosphataemia in clinical trials?Which body areas can be used for subcutaneous burosumab injections?

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