How should Qdenga be mixed during reconstitution to avoid forming foam and bubbles?

To reconstitute Qdenga, use only the supplied solvent, direct it slowly towards the vial wall, release your finger from the plunger, then gently swirl in both directions on a flat surface with the needle–syringe assembly attached; do not shake, as foam and bubbles may form, and let stand until clear (about 30–60 seconds).