Answer
Ketoconazole may affect levobupivacaine hydrochloride metabolism by inhibiting CYP3A4, an enzyme implicated in its metabolism by in vitro studies, although no clinical studies have been conducted.
Sources for this answer
- Levobupivacaine 7.5 mg/ml solution for injection/infusionMartindale Pharma, an Ethypharm Group Company · emc · SmPC §4.5 Interaction with other medicinal products · Version 3Document updated
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