Answer
In patients with cystic fibrosis taking tezacaftor once daily and ivacaftor twice daily, steady-state plasma concentrations are reached within 8 days for tezacaftor and within 3–5 days for ivacaftor after starting treatment.
Sources for this answer
- Symkevi 100 mg/150 mg tablets PLGB 22352/0003Vertex Pharmaceuticals (Europe) Limited · emc · SmPC §5.2 Pharmacokinetic properties · Version 14Document updated
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