Answer
The theophylline component of aminophylline hydrate is metabolised in the liver, with metabolites excreted in urine and about 10% excreted unchanged in adults; hepatic metabolism varies considerably between individuals, affecting clearance, serum concentrations and half-lives, while cigarette smoking increases clearance and shortens serum half-life.
Sources for this answer
- Aminophylline hydrate 25mg/ml Solution for injectionADVANZ Pharma · emc · SmPC §5.2 Pharmacokinetic properties · Version 8Document updated
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