Answer
Paracetamol in caffeine + paracetamol probably reduces fever by acting on the hypothalamic heat-regulating centre, probably inhibiting prostaglandin synthesis there, to produce peripheral vasodilation, increased skin blood flow, sweating and heat loss.
Sources for this answer
- Paracetamol and Caffeine 500mg / 65mg TabletsFlamingo Pharma (UK) Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 1Document updated
Sources checked