rivastigmine · Medicine question

How is rivastigmine primarily metabolised?

iatroX medicinesPublished 8 November 2026

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Rivastigmine is primarily metabolised by cholinesterase-mediated hydrolysis to NAP226-90, with major cytochrome P450 isoenzymes minimally involved according to animal studies.

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Exelon 4.6 mg/24h, 9.5 mg/24h, 13.3 mg/24h transdermal patchNovartis Pharmaceuticals UK Ltd · emc · SmPC §5.2 Pharmacokinetic properties · Version 21Document updated 22 October 2025

Sources checked 8 November 2026

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