Answer
Remimazolam besylate is rapidly converted by liver carboxylesterases, primarily CES-1/type 1A, into the pharmacologically inactive carboxylic acid metabolite CNS7054, which undergoes limited further hydroxylation and glucuronidation, with no meaningful cytochrome P450 contribution to CNS7054 formation.
Sources for this answer
- Byfavo 20mg powder for solution for injectionPAION UK Ltd · emc · SmPC §5.2 Pharmacokinetic properties · Version 3Document updated
Sources checked