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Medicines patisiran sodiumQuestion & answer

patisiran sodium · Medicine question

How is patisiran sodium metabolised in the body?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Patisiran sodium (Onpattro) is metabolised by nucleases to nucleotides of various lengths and is not a substrate of cytochrome P450 enzymes.

Sources for this answer

Onpattro 2 mg/mL concentrate for solution for infusion.Alnylam UK Ltd · emc · SmPC §5.2 Pharmacokinetic properties · Version 12Document updated 18 June 2026

Sources checked 8 November 2026

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Does patisiran sodium (Onpattro) affect the ability to drive or use machines?Have the safety and efficacy of patisiran sodium (Onpattro) been established in children and adolescents under 18?How does patisiran sodium (Onpattro) reduce transthyretin protein levels?How much sodium does each mL of patisiran sodium (Onpattro) concentrate contain?What are the most common symptoms of infusion-related reactions to patisiran sodium (Onpattro)?

patisiran sodium

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