How is eszopiclone thought to promote sleep?

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Eszopiclone’s precise mechanism is unknown, but it is believed to modulate GABA-A receptor complexes containing alpha-1, alpha-2, alpha-3 and alpha-5 subunits, increasing GABA-evoked chloride conductance, hyperpolarising neurons and inhibiting neuronal transmission to cause sleep.

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Lunivia 1 mg film-coated tabletsaxunio Pharma GmbH · emc · SmPC §5.1 Pharmacodynamic properties · Version 2Document updated 20 February 2026

Sources checked 8 November 2026

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