Answer
Although its exact mechanism is not fully understood, dexrazoxane hydrochloride (Cardioxane) and its ring-opened product ICRF-198 are thought to chelate metal ions, preventing iron–anthracycline complexes from redox cycling and generating reactive radicals that damage cardiac muscle.
Sources for this answer
- CARDIOXANE 500 mg powder for solution for infusionCNX Therapeutics Ltd (formerly Sunovion Pharmaceuticals Europe) · emc · SmPC §5.1 Pharmacodynamic properties · Version 1Document updated
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