Answer
Zilucoplan sodium binds C5, inhibiting its cleavage by C5 convertase into C5a and C5b, and binds the C5b moiety to sterically hinder C6 binding if C5b forms, thereby inhibiting membrane attack complex assembly and activity.
Sources for this answer
- Zilbrysq 32.4 mg solution for injection in pre filled syringeUCB Pharma Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 3Document updated
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