Answer
Zidovudine is converted by cellular enzymes into zidovudine triphosphate, which inhibits HIV reverse transcriptase; incorporation of zidovudine monophosphate into the growing DNA chain terminates it, blocking further proviral DNA formation.
Sources for this answer
- Retrovir10 mg/ml IV for InfusionViiV Healthcare UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 34Document updated
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