Answer
Venetoclax binds directly to the BH3-binding groove of BCL-2, displacing BH3 motif-containing pro-apoptotic proteins such as BIM and initiating mitochondrial outer membrane permeabilization, caspase activation and programmed cell death.
Sources for this answer
- Venclyxto 10mg film-coated tabletsAbbVie Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 26Document updated
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