How does using oxymetazoline hydrochloride before nafarelin acetate nasal spray affect nafarelin absorption?

In subjects with perennial rhinitis, oxymetazoline hydrochloride used 30 minutes before nafarelin acetate significantly reduced nafarelin absorption, decreasing AUC0–8h by 39% and Cmax by 49% compared with subjects with normal nasal mucosa; concomitant decongestant use is discouraged.