Answer
Trifluridine/tipiracil inhibits cancer cell proliferation through trifluridine, which is phosphorylated by thymidine kinase, metabolised to a DNA substrate and incorporated into DNA, disrupting its function; tipiracil inhibits thymidine phosphorylase, which otherwise rapidly degrades trifluridine.
Sources for this answer
- Trifluridine/Tipiracil ServierServier Laboratories Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 12Document updated
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