trastuzumab · Medicine question

How does trastuzumab binding affect HER2 signalling?

iatroX medicinesPublished 8 November 2026

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Answer

Trastuzumab binds to sub-domain IV of HER2’s extracellular domain, inhibiting ligand-independent HER2 signalling and preventing proteolytic cleavage of the extracellular domain, an HER2 activation mechanism.

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Herceptin 150mg Powder for concentrate for solution for infusionRoche Products Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 52Document updated 5 January 2026

Sources checked 8 November 2026

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