Answer
Trabectedin binds to DNA’s minor groove and bends the helix towards the major groove, triggering a cascade affecting transcription factors, DNA-binding proteins and DNA repair pathways that disrupts the cell cycle.
Sources for this answer
- Yondelis 0.25 mg powder for concentrate for solution for infusionImmedica · emc · SmPC §5.1 Pharmacodynamic properties · Version 23Document updated
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