Answer
Thiotepa is believed to release ethylene imine radicals that disrupt DNA bonds, for example by alkylating guanine at N-7, breaking the linkage between the purine base and sugar and releasing alkylated guanine.
Sources for this answer
- Thiotepa Riemser 15 mg powder for concentrate for solution for infusionEsteve Pharmaceuticals (formerly Intrapharm Laboratories) · emc · SmPC §5.1 Pharmacodynamic properties · Version 3Document updated
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