Answer
The tramadol component of paracetamol + tramadol acts centrally as a pure, non-selective μ, δ and κ opioid-receptor agonist, with higher affinity for μ receptors, and also inhibits neuronal noradrenaline reuptake and enhances serotonin release.
Sources for this answer
- Tramacet 37.5 mg/ 325 mg film-coated tabletsGrunenthal Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 18Document updated
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