Answer
SG3199 released by loncastuximab tesirine binds to the DNA minor groove and forms highly cytotoxic DNA interstrand crosslinks, subsequently inducing cell death.
Sources for this answer
- Zynlonta, 10mg, powder for concentrate for solution for infusionSwedish Orphan Biovitrum Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 8Document updated
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