Answer
In Innozide (enalapril maleate + hydrochlorothiazide), enalapril becomes enalaprilat, which inhibits ACE and reduces angiotensin II formation and aldosterone secretion; blood-pressure lowering is believed to occur primarily through suppression of the renin–angiotensin–aldosterone system, although enalapril also works in low-renin hypertension.
Sources for this answer
- Innozide TabletsOrganon Pharma (UK) Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 26Document updated
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