cobicistat + elvitegravir + emtricitabine + tenofovir alafenamide fumarate · Medicine question

How does the elvitegravir component of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide block HIV-1 replication?

iatroX medicinesPublished 8 November 2026

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Elvitegravir in elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide inhibits HIV-1 integrase strand transfer, preventing integration of viral DNA into host genomic DNA and thereby blocking HIV-1 provirus formation and propagation of infection.

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Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Gilead 150mg/150mg/200mg/10mg film coated tabletsGilead Sciences Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 37Document updated 22 October 2025

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