Answer
After mirvetuximab soravtansine binds folate receptor alpha and is internalised, DM4 is released intracellularly by proteolytic cleavage and disrupts the cell’s microtubule network, causing cell-cycle arrest and apoptotic cell death.
Sources for this answer
- ELAHERE 5 mg/mL concentrate for solution for infusionAbbVie Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 2Document updated
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