terbinafine hydrochloride · Medicine question

How does terbinafine kill fungal cells?

iatroX medicinesPublished 8 November 2026

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Terbinafine inhibits squalene epoxidase in the fungal cell membrane, disrupting sterol biosynthesis and causing ergosterol deficiency and intracellular squalene accumulation that lead to fungal cell death.

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Lamisil OnceKaro Pharma AB · emc · SmPC §5.1 Pharmacodynamic properties · Version 12Document updated 30 June 2025

Sources checked 8 November 2026

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