terbinafine · Medicine question

How does terbinafine kill fungal cells?

iatroX medicinesPublished 8 November 2026

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Answer

Terbinafine inhibits squalene epoxidase in the fungal cell membrane, disrupting sterol biosynthesis and causing ergosterol deficiency and intracellular squalene accumulation, resulting in fungal cell death.

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Lamisil AT 1% GelKaro Pharma AB · emc · SmPC §5.1 Pharmacodynamic properties · Version 9Document updated 4 March 2024

Sources checked 8 November 2026

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Which fungal skin infections is Lamisil AT 1% Gel (terbinafine) indicated to treat?Can Lamisil AT 1% Gel (terbinafine) be used while breastfeeding?How should the skin be prepared before applying Lamisil AT 1% Gel (terbinafine)?Is Lamisil AT 1% Gel (terbinafine) suitable for children under 16?What common skin side effects can occur with Lamisil AT 1% Gel (terbinafine)?What precaution applies to using other medicines on skin treated with Lamisil AT 1% Gel (terbinafine)?

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