tepotinib hydrochloride hydrate · Medicine question

How does tepotinib affect HGF-dependent and HGF-independent MET phosphorylation?

Name: How does tepotinib affect HGF-dependent and HGF-independent MET phosphorylation?
Published: 2026-11-08T14:36:59.778Z

iatroX medicinesPublished 8 November 2026

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Tepotinib inhibits both hepatocyte growth factor (HGF)-dependent and HGF-independent MET phosphorylation and MET-dependent downstream signalling pathways.

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Tepotinib 225 mg film-coated tabletsMerck · emc · SmPC §5.1 Pharmacodynamic properties · Version 2Document updated 28 October 2026

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