Answer
Tenofovir disoproxil is converted to tenofovir and then to tenofovir diphosphate, which inhibits HIV-1 reverse transcriptase and hepatitis B virus polymerase by competing with the natural deoxyribonucleotide substrate and terminating DNA chains after incorporation into DNA.
Sources for this answer
- Tenofovir Disoproxil Sandoz 245 mg Film-coated TabletsSandoz Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 9Document updated
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