Answer
Tenofovir disoproxil fumarate is converted to tenofovir and then to tenofovir diphosphate, which inhibits HIV-1 reverse transcriptase and hepatitis B virus polymerase by competing with the natural deoxyribonucleotide substrate for binding and terminating DNA chains after incorporation.
Sources for this answer
- Viread 245 mg film-coated tabletsGilead Sciences Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 61Document updated
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