Answer
Tenofovir alafenamide fumarate is converted in hepatocytes to tenofovir and then phosphorylated to active tenofovir diphosphate, which is incorporated into viral DNA by hepatitis B virus reverse transcriptase, causing DNA chain termination and inhibiting viral replication.
Sources for this answer
- Vemlidy 25 mg film coated tabletsGilead Sciences Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 16Document updated
Sources checked