sumatriptan · Medicine question

How does sumatriptan work to relieve migraine?

iatroX medicinesPublished 8 November 2026

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Sumatriptan activates vascular 5-HT1d receptors, causing cranial blood vessel constriction, and animal studies suggest it inhibits trigeminal nerve activity; both effects may contribute to migraine relief in humans.

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Imigran 10mg Nasal SprayGlaxoSmithKline UK · emc · SmPC §5.1 Pharmacodynamic properties · Version 14Document updated 27 October 2025

Sources checked 8 November 2026

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