Answer
Sulfamethoxazole + trimethoprim potentiates warfarin’s anticoagulant activity through stereo-selective inhibition of its metabolism, while sulfamethoxazole may also displace warfarin from plasma-albumin binding sites in vitro, so careful control of anticoagulant therapy is advisable during treatment.
Sources for this answer
- Co-Trimoxazole 16 mg/ 80 mg per ml for Infusion.Aspen · emc · SmPC §4.5 Interaction with other medicinal products · Version 15Document updated
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