sulfadiazine · Medicine question

How does sulfadiazine inhibit bacterial folic acid synthesis?

iatroX medicinesPublished 8 November 2026

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Sulfadiazine is a structural analogue and competitive antagonist of p-aminobenzoic acid (PABA), preventing bacteria from using PABA to synthesise folic acid.

Sources for this answer

Sulfadiazine 500mg Tablets BPWockhardt UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 5Document updated 14 December 2015

Sources checked 8 November 2026

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