Answer
Stiripentol directly positively modulates GABA-A receptors allosterically, preferentially affecting alpha3 and delta subunits, and has been shown to increase chloride-channel mean opening duration, but not frequency, thereby enhancing inhibitory GABAergic currents.
Sources for this answer
- Diacomit 250mg hard capsulesAlan Pharmaceuticals · emc · SmPC §5.1 Pharmacodynamic properties · Version 6Document updated
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