Answer
St John's wort induces CYP3A4 and may substantially reduce exposure to dasatinib, potentially increasing the risk of therapeutic failure; an alternative with less potential for CYP3A4 induction should be selected.
Sources for this answer
- Sprycel 20mg, 50mg, 80mg, 100mg and 140mg Film Coated TabletsBristol Myers Squibb Pharmaceuticals limited · emc · SmPC §4.4 Special warnings and precautions for use · Version 21Document updated
Sources checked