Answer
Sotorasib covalently and irreversibly binds the unique cysteine of KRAS G12C, engaging both the P2 pocket and His95 surface groove to lock the protein in an inactive state that prevents downstream signalling without affecting wild-type KRAS.
Sources for this answer
- LUMYKRAS 240 mg film-coated tabletsAmgen Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 3Document updated
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