Answer
SN-38 released by sacituzumab govitecan interacts with topoisomerase I and prevents re-ligation of topoisomerase I-induced single-strand DNA breaks, causing DNA damage that leads to apoptosis and cell death.
Sources for this answer
- Trodelvy 180 mg powder for concentrate for solution for infusionGilead Sciences Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 11Document updated
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