Answer
After oral ingestion, simvastatin is converted in the liver from an inactive lactone into its active beta-hydroxyacid form, which inhibits HMG-CoA reductase, the enzyme converting HMG-CoA to mevalonate in an early, rate-limiting step of cholesterol biosynthesis.
Sources for this answer
- Zocor 10mg, 20mg and 40mg film-coated tabletsOrganon Pharma (UK) Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 50Document updated
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