How does severe renal impairment affect systemic exposure to glycopyrronium in Trimbow 87/5/9 micrograms pressurised inhaler?

In Trimbow 87/5/9 micrograms pressurised inhaler, severe renal impairment (glomerular filtration rate below 30 mL/min/1.73 m²) increased total systemic exposure to glycopyrronium by up to 2.5-fold, owing to approximately 90% lower glycopyrronium renal clearance.